Investigation of “Kien ty chi thong - HV” granules for acute and subchronic oral toxicity in experimental animals

This research is to evaluate the acute and subchronic toxicities of “Kien ty chi thong - HV” granules through oral administration in experimental animals. The toxicity was determined by Litchfield Wilcoxon method Swiss mice. evaluated WHO OECD’s recommendation Wistar rats with doses 1.8 g/kg/day (equal recommended human dose) 5.4 (3 times as high 4 consecutive weeks. As a result, at highest dose used mice (56.25 g/kg) did not express In terms test, after granules, hematological parameters, hepato-renal functions, microscopic images liver kidney were unchanged compared control group. conclusion, produce rats.